7 Comments
Apr 10, 2023Liked by Andrew R. Gallimore

Could the insertion of designer receptors at specific brain sites one day potentially aid in permanently restoring proper neuronal network connectivity in certain diseases and disorders?

Sincerely thankful for all your public content, it's greatly enhancing my pharmacology studies.

Expand full comment

Why hasn’t molecular bio post 93 ie SNPs and genotypical receptor selectivity and counter consequence not been mentioned yet? Or is that after the interest-popularity wave?

Expand full comment

I’m wondering how a DREADD can be so selective even given the mutated structure. Certainly it may have some affinity with additional ligands, whether endogenous or exogenous, right? Is the idea here to simply vastly reduce the number of alternative ligands, and have it be that if there are secondary ligands w/ minor affinity, the effect is so weak that it would not induce intracellular cascades or changes in membrane potential?

Expand full comment

You go first.

Expand full comment