16 Comments
Mar 5, 2023Liked by Andrew R. Gallimore

Thank you for elucidating this paper. Greatly appreciated.

Do we currently have a clear understanding of why different signaling biases result in the various subjective effects of, for example, LSD versus LSA? Or do we only know that this is the case without further insight into how and why it happens?

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This does not explain "long LSD" - like long COVID :)

As I rose up the ranks of the scientific and corporate world I started to wonder: where did all the acid heads go? Very few people who regularly dropped acid avoided dropping out.

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Since LSD is taken as a tartrate, i.e., the position-6 Nitrogen is protonated, is it then still the protonated molecule that winds up at receptors?

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You say LSD is just right, does this mean it is perfect or is there potential to improve it further?

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Nice write up! How feasible do you think it would be to concoct (protein engineering perhaps?) a LSD-esque DMT molecule that has the same binding properties? Perhaps including ergoline structure in it. Just curious if it even makes sense.

Thanks!

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