Very interesting (and horrifying) post, thanks so much. I was wondering if (and if not, why not) any secret services have ever used such compounds to poison enemies or captives (mk ultra aside). Russia has an ongoing poisoning program with radioactive polonium that killed Litvinenko, Skripal and Navalny nearly died of an agent called Novichok. And the Russians for sure arent alone here, thinking about failed American attempts to poison Fidel Castro.
Not expecting a definite answer of course (and I hope I am not giving anyone nee ideas ;-)) but that would make a lot of sense, wouldn't be hard to manufacture for a government or to dose a target...
I'm confused on the 3 day thing; presumeably covalently bound agonists are going to be destroyed when the receptor is internalized, degraded, and replaced. Is KOR turned over that slowly? Are the neurons returning the same covalently bound receptor to the synapse for three whole days, taking a % to the proteosome each time they get to the surface?
I guess my mental model for drugs that would have an effect for that long would focus on ones that evade metobolic destruction or take time to get to the brain. Many benzos fall into this category, prozac takes a long time to be eliminated, the list of commercial phamecuticals is pretty long. The Edgewood Arsenal experiments dabbled quite a bit in exploring substances that stick around in the body forever. In the psychoactive space, I think of 2CB/DOB/Dragonfly and what slowing down metabolism can do to the duration of activity.
I think my fear outweighs my curiosity when it comes to salvia... Jesus Christ. Fascinating though! Two common things I hear from salvia trip reports are (like you mentioned) experiences of other lives, and experiences of being inanimate objects, like rocks. I have no idea what the range of metaphysical implications of these experiences could be, but I think it must be more than just “drugs make us think weird stuff”.
Hopefully we will investigate these experiences scientifically one day. Maybe not RB-64 though... No theory of consciousness is complete without taking these kinds of psychedelic states into consideration.
Very interesting (and horrifying) post, thanks so much. I was wondering if (and if not, why not) any secret services have ever used such compounds to poison enemies or captives (mk ultra aside). Russia has an ongoing poisoning program with radioactive polonium that killed Litvinenko, Skripal and Navalny nearly died of an agent called Novichok. And the Russians for sure arent alone here, thinking about failed American attempts to poison Fidel Castro.
Not expecting a definite answer of course (and I hope I am not giving anyone nee ideas ;-)) but that would make a lot of sense, wouldn't be hard to manufacture for a government or to dose a target...
I'm confused on the 3 day thing; presumeably covalently bound agonists are going to be destroyed when the receptor is internalized, degraded, and replaced. Is KOR turned over that slowly? Are the neurons returning the same covalently bound receptor to the synapse for three whole days, taking a % to the proteosome each time they get to the surface?
I guess my mental model for drugs that would have an effect for that long would focus on ones that evade metobolic destruction or take time to get to the brain. Many benzos fall into this category, prozac takes a long time to be eliminated, the list of commercial phamecuticals is pretty long. The Edgewood Arsenal experiments dabbled quite a bit in exploring substances that stick around in the body forever. In the psychoactive space, I think of 2CB/DOB/Dragonfly and what slowing down metabolism can do to the duration of activity.
I think my fear outweighs my curiosity when it comes to salvia... Jesus Christ. Fascinating though! Two common things I hear from salvia trip reports are (like you mentioned) experiences of other lives, and experiences of being inanimate objects, like rocks. I have no idea what the range of metaphysical implications of these experiences could be, but I think it must be more than just “drugs make us think weird stuff”.
Hopefully we will investigate these experiences scientifically one day. Maybe not RB-64 though... No theory of consciousness is complete without taking these kinds of psychedelic states into consideration.