I am an undergraduate genetics major that has taken Gen Chem I, II, Orgo I, II, and Biochemistry, and I am in a pharmacogenomics class where I learned the basics of pharmacology, so it is cool to see you neatly tie everything together in posts about psychedelics! Also, quick question on the bromine. I believe in the article you said that bromine was included because it is (more hydrophobic?) than the methyl group. My understanding was that bromine was polarizable and could induce a dipole thus making it more hydrophilic as opposed to hydrophobic: what am I missing? Thank you very much, this post has made my plane ride much better!
In an alkane you're correct. But bromine is an aryl substituent here and gives some electrons back in delocalisation with the ring electrons. Both bromo- and iodo- substituents are surprisingly hydrophobic. You need to look at the partition coefficient to get a measure of the hydrophibicity of aromatic substituents: Methyl: 0.51; Br: 0.94; Iodo: 1.15.
Furan rings aren't special in and of themselves. The DragonFLY furans are perfectly positioned to interact with the serines in the 5HT2A receptor important for binding/activation. You can't just add a furan ring to a molecule and expect it to have an effect... doing so would most likely make the molecule completely inactive by preventing binding.
Similar question. How could one make lsd last longer. With the onset of analogs this could be n interesting.
I am an undergraduate genetics major that has taken Gen Chem I, II, Orgo I, II, and Biochemistry, and I am in a pharmacogenomics class where I learned the basics of pharmacology, so it is cool to see you neatly tie everything together in posts about psychedelics! Also, quick question on the bromine. I believe in the article you said that bromine was included because it is (more hydrophobic?) than the methyl group. My understanding was that bromine was polarizable and could induce a dipole thus making it more hydrophilic as opposed to hydrophobic: what am I missing? Thank you very much, this post has made my plane ride much better!
In an alkane you're correct. But bromine is an aryl substituent here and gives some electrons back in delocalisation with the ring electrons. Both bromo- and iodo- substituents are surprisingly hydrophobic. You need to look at the partition coefficient to get a measure of the hydrophibicity of aromatic substituents: Methyl: 0.51; Br: 0.94; Iodo: 1.15.
Got it, that makes sense. Thanks!
Hey bud, brilliant article even though most of the technical went over my head :D
I'm wondering, can they apply the Furan Ring to other molecules, like LSD-25, making an extremely long but safe trip.
Furan rings aren't special in and of themselves. The DragonFLY furans are perfectly positioned to interact with the serines in the 5HT2A receptor important for binding/activation. You can't just add a furan ring to a molecule and expect it to have an effect... doing so would most likely make the molecule completely inactive by preventing binding.
Thanks bud, don't feel the need to respond if the question is inane :D I do appreciate you taking the time though.