One question that popped into my head was that you are putting in 60-100 ng/ml and after looking it up it says that average levels of serotonin go from 50-200 ng/ml. I have little background in this subject and I’m not sure if it’s even a valid question but does this correlate in anyway since both work on the same 5HT receptors. Or would it have to be that way for anything working in those receptors?
No, you're correct. The concentration required to achieve an effect will depend on a number of factors, including how strongly a drug binds to the receptor and for how long. LSD, for example, is fully active at extremely low concentrations, since it binds strongly to the 5HT2A receptor and stays there for a *long* time. So the fact that DMT seems to be active in around the same concentration range as serotonin is interesting for sure. What does it mean? Open to interpretations.
Hi Andrew, love the substack format, reading all your work voraciously. I remember from the Psychadelic Neuroscience videos that you stated neural oscillations were affected and spikes in the theta bandwidth were generally observed towards the end of the trip. Im curious if the same will be true in with infusion technology? Im also extremely curious to hear what your thoughts are on the spike in theta activity....
I thought the concept behind DMT was no control over psychological effects? Full control of no control sounds like Xtreme sports. I smoked "toad sweat" once, but wouldn't want to hang out there.
There's no such concept. Sure, there is usually little control, but here we're controlling brain concentration and *depth* of experience, not the content of the experience.
Sure, purging is certainly variable, although in many ayahuasca preparations, purgative plants are added to *induce* purging, since many consider it an important part of the process. I'm sure it can be reduced if desired. However, this is really a minor point I was making -- the key difference between ayahuasca and DMTx is the real-time control over brain DMT concentrations which you simply can't achieve with ayahuasca.
One question that popped into my head was that you are putting in 60-100 ng/ml and after looking it up it says that average levels of serotonin go from 50-200 ng/ml. I have little background in this subject and I’m not sure if it’s even a valid question but does this correlate in anyway since both work on the same 5HT receptors. Or would it have to be that way for anything working in those receptors?
No, you're correct. The concentration required to achieve an effect will depend on a number of factors, including how strongly a drug binds to the receptor and for how long. LSD, for example, is fully active at extremely low concentrations, since it binds strongly to the 5HT2A receptor and stays there for a *long* time. So the fact that DMT seems to be active in around the same concentration range as serotonin is interesting for sure. What does it mean? Open to interpretations.
Hi Andrew, love the substack format, reading all your work voraciously. I remember from the Psychadelic Neuroscience videos that you stated neural oscillations were affected and spikes in the theta bandwidth were generally observed towards the end of the trip. Im curious if the same will be true in with infusion technology? Im also extremely curious to hear what your thoughts are on the spike in theta activity....
I know you have a lot of volunteers but pick me pick me pick me :)
I thought the concept behind DMT was no control over psychological effects? Full control of no control sounds like Xtreme sports. I smoked "toad sweat" once, but wouldn't want to hang out there.
There's no such concept. Sure, there is usually little control, but here we're controlling brain concentration and *depth* of experience, not the content of the experience.
Sure, purging is certainly variable, although in many ayahuasca preparations, purgative plants are added to *induce* purging, since many consider it an important part of the process. I'm sure it can be reduced if desired. However, this is really a minor point I was making -- the key difference between ayahuasca and DMTx is the real-time control over brain DMT concentrations which you simply can't achieve with ayahuasca.