Great article as always! What would be your thoughts on wether the duration of NN-DMT could be extended by pindalol or some other beta blocker or other molecule? Wondering if the subjective experience would differ from extending the state via MAO inhibition….
To avoid complicated drug design, I think I'll just do what Lily envisioned (before his therapist talked him out of it) which is a series of electrodes connected to each individual neuron.
Then I'll pump voltage to each and see if I can get my desired receptor subtype activation combination. If I don't reply to this in 3 days then something has gone terribly wrong.
This looks straight out of science-fiction, except it seems very doable in the near future. If we couple these ideas with a future bigger knowledge about how different psychopathologies correspond to different brain circuits and hence receptors, we could hypothetically have different psychedelic combinations for specific psychopathologies.
Great article as always! What would be your thoughts on wether the duration of NN-DMT could be extended by pindalol or some other beta blocker or other molecule? Wondering if the subjective experience would differ from extending the state via MAO inhibition….
To avoid complicated drug design, I think I'll just do what Lily envisioned (before his therapist talked him out of it) which is a series of electrodes connected to each individual neuron.
Then I'll pump voltage to each and see if I can get my desired receptor subtype activation combination. If I don't reply to this in 3 days then something has gone terribly wrong.
Very thorough and entertaining breakdown! This makes me imagine a periodic table of receptor interactions for easy visual navigation
This looks straight out of science-fiction, except it seems very doable in the near future. If we couple these ideas with a future bigger knowledge about how different psychopathologies correspond to different brain circuits and hence receptors, we could hypothetically have different psychedelic combinations for specific psychopathologies.