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The Psyche Deli's avatar

Great article as always! What would be your thoughts on wether the duration of NN-DMT could be extended by pindalol or some other beta blocker or other molecule? Wondering if the subjective experience would differ from extending the state via MAO inhibition….

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Andrew R. Gallimore's avatar

Since pindolol is acting independently of DMT, it won't affect its pharmacokinetics/dynamics, so the experience will be about the same length -- just more intense.

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The Psyche Deli's avatar

Ah I see! That makes sense, there i was hoping in vain for a new extended state possibility! Very interesting my about the LSM-775 aswell! Cheers

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entropy labs's avatar

beautifully written.. "psychedelicy" 🤌🏼

I have even been thinking about the other less talked about receptors.. for instance.. should we also minimize activation of the 5HT2B receptor in this cocktail? Or should we just add a 5HT2B antagonist? I love the example of 5-MeO vs N,N but I often wonder what is happening with the other 14 receptors? This is a very promising strategy for "removing the trip" but I wonder if the neurobiology is still the same? Would a dampened trip still have the beneficial neuroplasticity?

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Frank Beans's avatar

To avoid complicated drug design, I think I'll just do what Lily envisioned (before his therapist talked him out of it) which is a series of electrodes connected to each individual neuron.

Then I'll pump voltage to each and see if I can get my desired receptor subtype activation combination. If I don't reply to this in 3 days then something has gone terribly wrong.

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Collin Kauri's avatar

Very thorough and entertaining breakdown! This makes me imagine a periodic table of receptor interactions for easy visual navigation

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Cerasus's avatar

This looks straight out of science-fiction, except it seems very doable in the near future. If we couple these ideas with a future bigger knowledge about how different psychopathologies correspond to different brain circuits and hence receptors, we could hypothetically have different psychedelic combinations for specific psychopathologies.

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