Great article as always! What would be your thoughts on wether the duration of NN-DMT could be extended by pindalol or some other beta blocker or other molecule? Wondering if the subjective experience would differ from extending the state via MAO inhibition….
Since pindolol is acting independently of DMT, it won't affect its pharmacokinetics/dynamics, so the experience will be about the same length -- just more intense.
I have even been thinking about the other less talked about receptors.. for instance.. should we also minimize activation of the 5HT2B receptor in this cocktail? Or should we just add a 5HT2B antagonist? I love the example of 5-MeO vs N,N but I often wonder what is happening with the other 14 receptors? This is a very promising strategy for "removing the trip" but I wonder if the neurobiology is still the same? Would a dampened trip still have the beneficial neuroplasticity?
To avoid complicated drug design, I think I'll just do what Lily envisioned (before his therapist talked him out of it) which is a series of electrodes connected to each individual neuron.
Then I'll pump voltage to each and see if I can get my desired receptor subtype activation combination. If I don't reply to this in 3 days then something has gone terribly wrong.
This looks straight out of science-fiction, except it seems very doable in the near future. If we couple these ideas with a future bigger knowledge about how different psychopathologies correspond to different brain circuits and hence receptors, we could hypothetically have different psychedelic combinations for specific psychopathologies.
Great article as always! What would be your thoughts on wether the duration of NN-DMT could be extended by pindalol or some other beta blocker or other molecule? Wondering if the subjective experience would differ from extending the state via MAO inhibition….
Since pindolol is acting independently of DMT, it won't affect its pharmacokinetics/dynamics, so the experience will be about the same length -- just more intense.
Ah I see! That makes sense, there i was hoping in vain for a new extended state possibility! Very interesting my about the LSM-775 aswell! Cheers
beautifully written.. "psychedelicy" 🤌🏼
I have even been thinking about the other less talked about receptors.. for instance.. should we also minimize activation of the 5HT2B receptor in this cocktail? Or should we just add a 5HT2B antagonist? I love the example of 5-MeO vs N,N but I often wonder what is happening with the other 14 receptors? This is a very promising strategy for "removing the trip" but I wonder if the neurobiology is still the same? Would a dampened trip still have the beneficial neuroplasticity?
To avoid complicated drug design, I think I'll just do what Lily envisioned (before his therapist talked him out of it) which is a series of electrodes connected to each individual neuron.
Then I'll pump voltage to each and see if I can get my desired receptor subtype activation combination. If I don't reply to this in 3 days then something has gone terribly wrong.
Very thorough and entertaining breakdown! This makes me imagine a periodic table of receptor interactions for easy visual navigation
This looks straight out of science-fiction, except it seems very doable in the near future. If we couple these ideas with a future bigger knowledge about how different psychopathologies correspond to different brain circuits and hence receptors, we could hypothetically have different psychedelic combinations for specific psychopathologies.